Application of Botulinum toxin – removing mimic wrinkles and removing unwanted perspiration – Hyperhidrosis

Botulinum toxin is a neurotoxin produced by Clostridium botulinum bacteria and it has been in clinical practice for 25 years (beside dermatology it is neurology, ophthalmology), its´ use is safe (demonstrated by a number of medical studies), and doses used in aesthetic dermatology are 1000 times lower total toxic doses and 20 times lower than doses used in neurology.

Botulinum toxin to remove mimic wrinkles, after application to the muscle it blocks the transfer of information on the nerve-muscular system in the particular area, thus preventing contraction – the muscle stiffness. When applied in the face area, the muscle immobility and relaxation of the expressions (which causes the appearance of mimic wrinkles) occur within couple of days following. Depending on the technique, the area of application and the amount of substance used, the natural mimic is preserved, so although we can not create wrinkles in the applied areas of the face, it does not make the face to look stiffed. The wrinkles are extinguished, the face seems younger and relaxed. The effect is excellent especially for first wrinkles and wrinkles of middle-aged women. Concerning deep wrinkles, where the ligament has been definitive defected, and which persist even after interruption of the mimic movement, we recommend the application of filling materials.

The effects of botulinum toxin are also used in the treatment of excessive sweating – hyperhidrosis. It most often occurs as a result of emotions (joy, tension, nervousness, fear, stress). In this case, acetylcholine release is blocked – a substance released from the nerve endings which mediate the activity of the sweat glands. The result of blocking is paralysis of sweat gland activity.

Problems to be solved by botulinum toxin application

• Delicate mimic wrinkles on the face
• Excessive sweating – hyperhidrosis (not due to excessive sweating if it is a secondary symptom of another disease, for e.g. thyroid) – suitable for people allergic to antiperspirants and deodorants

When treatment is not appropriate.

• Hypersensitivity to the active substance
• Inflammation at the area of application
• Pregnancy, breastfeeding
• Blood clotting disorder, nerve-muscular diseases (Myastenia gravis, Lambert Eaton syndrome)
• Usage of some medicaments (local anesthetics, aminoglycoside antibiotics, non-steroidal anti-rheumatic drugs, myorelaxants, anticoagulants, calcium channel blockers, antimalarial drugs, cholinesterase inhibitors)

The most common areas for botulinum toxin applications.

• Forehead, the area above the root of the nose between the eyebrows – Glabela, eye area.
• Armpits, palms of hands and feet, face